Overview Of Serum Albumin Levels In Post-Sc Mothers With Preeclampsia At Bendan Regional General Hospital In Pekalongan City In 2025
Abstract
Preeclampsia remains a major cause of maternal morbidity and mortality and is frequently managed by cesarean section. Altered vascular permeability, proteinuria, and perioperative stress may contribute to reduced serum albumin concentrations. This study aimed to describe serum albumin levels among post-cesarean mothers with preeclampsia at Bendan Regional General Hospital, Pekalongan City, in 2025. A descriptive observational design with a retrospective approach was used. Secondary data were obtained from medical records and laboratory information systems and analyzed descriptively. Previous evidence indicates that hypoalbuminemia is common in preeclampsia and cesarean populations, with lower albumin concentrations associated with severe disease, proteinuria, fluid-related complications, and impaired postoperative recovery. Indonesian multicenter studies further demonstrate a high burden of severe preeclampsia and cesarean delivery. Serum albumin is a clinically relevant complementary laboratory parameter for evaluating post-cesarean mothers with preeclampsia. Its interpretation should be integrated with blood pressure, proteinuria, renal and hepatic function, fluid balance, and postoperative findings, rather than serving as an isolated marker of severity or postoperative prognosis in routine practice. These findings support hospital-based monitoring and further analytical research.
Downloads
References
Albert, C., Corlay, L., Beaumont, M., Smith, M., Communier, E. C., Nowak, E., Merviel, P., Tremouilhac, C., Hannigsberg, J., Herrmann, S., Dupré, P.-F., & De Moreuil, C. (2022). Validation Of The French Translation Of A Self-Administered Questionnaire Looking For A History Of Pre-Eclampsia. Pregnancy Hypertension, 28, 146–148. Https://Doi.Org/10.1016/J.Preghy.2022.04.001
Allison, S. P., & Lobo, D. N. (2024). The Clinical Significance Of Hypoalbuminaemia. Clinical Nutrition, 43(4), 909–914. Https://Doi.Org/10.1016/J.Clnu.2024.02.018
American College Of Obstetricians And Gynecologists. (2020). Gestational Hypertension And Preeclampsia. Obstetrics & Gynecology, 135(6), E237–E260. Https://Doi.Org/10.1097/Aog.0000000000003891
Astuti. (2018). Manajemen Data. Universitas Muhammadiyah Semarang.
Badiah, N., & Luar, S. Karya Ilmiah Akhir Asuhan Keperawatan Pada Pasien Dengan Preeklampsia Berat (Peb)+ Intra Uterine Fetaldeath (Iufd) Post Operasi Sectio Caesarea (Sc). Http://Repository.Itskesicme.Ac.Id/Id/Eprint/8111
Bakrania, B., Spradley, F., & Drummond, H. (2021). Preeclampsia: Linking Placental Ischemia With Maternal Endothelial And Vascular Dysfunction. Comprehensive Physiology, 11(1), 1315–1349.
Bardi, M. (2025). Could Low Serum Albumin Level Be An Independent Marker Of Severe Preeclampsia? Healthcare, 13(13), 1503.
Bdolah, Y., Lam, C., Rajakumar, A., Shivalingappa, V., Mutter, W., Sachs, B. P., Lim, K. H., Bdolah-Abram, T., Epstein, F. H., & Karumanchi, S. A. (2023). Twin Pregnancy And The Risk Of Preeclampsia: Bigger Placenta Or Relative Ischemia? American Journal Of Obstetrics And Gynecology, 198(4), 428.E1-428.E6. Https://Doi.Org/10.1016/J.Ajog.2007.10.783
Bernardi, M. (2023). Effective Albumin – A Novel Paradigm In The Management Of Decompensated Liver Cirrhosis. Journal Of Translational Internal Medicine, 11(1), 11–14. Https://Doi.Org/10.2478/Jtim-2022-0070
Bisri, D. Y., & Bisri, T. (2025). Preeklampsia Dan Risiko Penyakit Kardiovaskuler Di Masa Depan Preeclampsia And Risk Of Future Cardiovascular Disease. Jurnal Anestesi Obstetri Indonesia, 8, 61–68.
Cahyono, T. (2018). Statistika Terapan & Indikator Kesehatan. Deepublish.
Chang, K.-J., Seow, K.-M., & Chen, K.-H. (2023). Preeclampsia: Recent Advances In Predicting, Preventing, And Managing The Maternal And Fetal Life-Threatening Condition. International Journal Of Environmental Research And Public Health, 20(4), 2994. Https://Doi.Org/10.3390/Ijerph20042994
Ciciu, E., Alexandru, A., Cimpineanu, B., Musledin, S., Cioti, C., Pana, C., Stăniguț, A. M., & Tuta, L.-A. (2025). Could Low Serum Albumin Level Be An Independent Marker Of Severe Preeclampsia? Healthcare, 13(13), 1503. Https://Doi.Org/10.3390/Healthcare13131503
Çobanoğlu, U., Birge, Ö., Çetin, M., & Güven, E. S. G. (2024). Evaluation Of Maternal Ischemia-Modified Albumin Levels During Pregnancy And Their Effect On Fetal Birth Weight. Medicina (Lithuania), 60(9). Https://Doi.Org/10.3390/Medicina60091530
Cunningham, F., Leveno, K., & Bloom, S. (2022). Williams Obstetrics (26th Ed.). Mcgraw-Hill Education.
Deer, E., Herrock, O., Campbell, N., Cornelius, D., Fitzgerald, S., Amaral, L. M., & Lamarca, B. (2023). The Role Of Immune Cells And Mediators In Preeclampsia. Nature Reviews Nephrology, 19(4), 257–270. Https://Doi.Org/10.1038/S41581-022-00670-0
Fang, Y., Liao, G., Li, X., Fang, Y., & Gao, Y. (2025). Association Between Serum Albumin And 42-Day Postpartum Mortality In Women With Acute Fatty Liver Of Pregnancy: A Retrospective Study. Frontiers In Medicine, 12. Https://Doi.Org/10.3389/Fmed.2025.1574686
Gahayu, S. A. (2019). Metodologi Penelitian Kesehatan Masyarakat. Deepublish.
Gillespie, B. M., Ellwood, D., Thalib, L., Kumar, S., Mahomed, K., Kang, E., & Chaboyer, W. (2022). Incidence And Risk Factors For Surgical Wound Complications In Women With Body Mass Index ≫30 Kg/M2 Following Cesarean Delivery: A Secondary Analysis. Ajog Global Reports, 2(3), 100069. Https://Doi.Org/10.1016/J.Xagr.2022.100069
Gremese, E., Bruno, D., Varriano, V., Perniola, S., Petricca, L., & Ferraccioli, G. (2023). Serum Albumin Levels: A Biomarker To Be Repurposed In Different Disease Settings In Clinical Practice. In Journal Of Clinical Medicine (Vol. 12, Number 18). Multidisciplinary Digital Publishing Institute (Mdpi). Https://Doi.Org/10.3390/Jcm12186017
Guo, S., & Dipietro, L. (2024). Factors Affecting Wound Healing. Journal Of Dental Research, 89(3), 219–229.
Howlett, B., Rogo, E., & Shelton, T. G. (2020). Evidence-Based Practice For Health Professionals An Interprofessional Approach. Jones & Bartlett Learning.
Idris, H., & Sari, I. (2023). Factors Associated With The Completion Of Antenatal Care In Indonesia: A Cross-Sectional Data Analysis Based On The 2018 Indonesian Basic Health Survey. Belitung Nursing Journal, 9(1), 79–85. Https://Doi.Org/10.33546/Bnj.2380
Jellabing, A. R., Sir, A. B., Tedju Hinga, I. A., & Sakke Tira, D. (2025). Analisis Faktor Risiko Kejadian Preeklampsia Pada Ibu. Prepotif : Jurnal Kesehatan Masyarakat, 9(1), 922–932.
